Loss of MicroRNA-7 Regulation Leads to &#945;-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.

McMillan, Kirsty J; Murray, Tracey K; Bengoa-Vergniory, Nora; Cordero-Llana, Oscar; Cooper, Jane; Buckley, Amy; Wade-Martins, Richard; Uney, James B; O'Neill, Michael J; Wong, Liang F; Caldwell, Maeve A

Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.

McMillan, Kirsty J; Murray, Tracey K; Bengoa-Vergniory, Nora; Cordero-Llana, Oscar; Cooper, Jane; Buckley, Amy; Wade-Martins, Richard; Uney, James B; O'Neill, Michael J; Wong, Liang F; Caldwell, Maeve A.

Afiliação

McMillan KJ; Regenerative Medicine Laboratory, School of Clinical Sciences, Bristol BS1 8TH, UK.
Murray TK; Eli Lilly & Co. Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK.
Bengoa-Vergniory N; Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Center, Oxford OX1 3QX, UK.
Cordero-Llana O; Regenerative Medicine Laboratory, School of Clinical Sciences, Bristol BS1 8TH, UK.
Cooper J; Eli Lilly & Co. Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK.
Buckley A; Trinity College Institute for Neuroscience, Trinity College Dublin, Dublin 2, Ireland.
Wade-Martins R; Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Center, Oxford OX1 3QX, UK.
Uney JB; Regenerative Medicine Laboratory, School of Clinical Sciences, Bristol BS1 8TH, UK.
O'Neill MJ; Eli Lilly & Co. Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK.
Wong LF; Regenerative Medicine Laboratory, School of Clinical Sciences, Bristol BS1 8TH, UK.
Caldwell MA; Trinity College Institute for Neuroscience, Trinity College Dublin, Dublin 2, Ireland. Electronic address: maeve.caldwell@tcd.ie.

Mol Ther ; 25(10): 2404-2414, 2017 10 04.

Article em En | MEDLINE | ID: mdl-28927576

Assuntos

Neurônios Dopaminérgicos/metabolismo; MicroRNAs/metabolismo; Substância Negra/metabolismo; alfa-Sinucleína/metabolismo; Animais; Humanos; Lentivirus/genética; Locomoção/genética; Locomoção/fisiologia; Masculino; Camundongos Endogâmicos C57BL; MicroRNAs/genética; Doença de Parkinson/genética; Doença de Parkinson/metabolismo; alfa-Sinucleína/genética

Palavras-chave

Parkinson's disease; lentiviral vector; microRNA; microRNA-7; α-synuclein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Substância Negra / MicroRNAs / Alfa-Sinucleína / Neurônios Dopaminérgicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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