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Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.
Urban, Daniel J; Martinez, Natalia J; Davis, Mindy I; Brimacombe, Kyle R; Cheff, Dorian M; Lee, Tobie D; Henderson, Mark J; Titus, Steven A; Pragani, Rajan; Rohde, Jason M; Liu, Li; Fang, Yuhong; Karavadhi, Surendra; Shah, Pranav; Lee, Olivia W; Wang, Amy; McIver, Andrew; Zheng, Hongchao; Wang, Xiaodong; Xu, Xin; Jadhav, Ajit; Simeonov, Anton; Shen, Min; Boxer, Matthew B; Hall, Matthew D.
Afiliação
  • Urban DJ; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Martinez NJ; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Davis MI; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Brimacombe KR; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Cheff DM; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Lee TD; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Henderson MJ; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Titus SA; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Pragani R; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Rohde JM; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Liu L; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Fang Y; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Karavadhi S; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Shah P; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Lee OW; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Wang A; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • McIver A; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine, Chapel Hill, 27599, North Carolina, United States.
  • Zheng H; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine, Chapel Hill, 27599, North Carolina, United States.
  • Wang X; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine, Chapel Hill, 27599, North Carolina, United States.
  • Xu X; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Jadhav A; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Simeonov A; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Shen M; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Boxer MB; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States.
  • Hall MD; NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, 20850, United States. hallma@mail.nih.gov.
Sci Rep ; 7(1): 12758, 2017 10 06.
Article em En | MEDLINE | ID: mdl-28986582
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Avaliação Pré-Clínica de Medicamentos / Inibidores Enzimáticos / Descoberta de Drogas / Isocitrato Desidrogenase / Mutação Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Avaliação Pré-Clínica de Medicamentos / Inibidores Enzimáticos / Descoberta de Drogas / Isocitrato Desidrogenase / Mutação Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article