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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.
Riggs, Jennifer R; Nagy, Mark; Elsner, Jan; Erdman, Paul; Cashion, Dan; Robinson, Dale; Harris, Roy; Huang, Dehua; Tehrani, Lida; Deyanat-Yazdi, Gordafaried; Narla, Rama Krishna; Peng, Xiaohui; Tran, Tam; Barnes, Leo; Miller, Terra; Katz, Jason; Tang, Yang; Chen, Ming; Moghaddam, Mehran F; Bahmanyar, Sogole; Pagarigan, Barbra; Delker, Silvia; LeBrun, Laurie; Chamberlain, Philip P; Calabrese, Andrew; Canan, Stacie S; Leftheris, Katerina; Zhu, Dan; Boylan, John F.
Afiliação
  • Riggs JR; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Nagy M; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Elsner J; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Erdman P; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Cashion D; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Robinson D; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Harris R; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Huang D; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Tehrani L; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Deyanat-Yazdi G; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Narla RK; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Peng X; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Tran T; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Barnes L; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Miller T; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Katz J; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Tang Y; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Chen M; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Moghaddam MF; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Bahmanyar S; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Pagarigan B; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Delker S; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • LeBrun L; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Chamberlain PP; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Calabrese A; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Canan SS; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Leftheris K; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Zhu D; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Boylan JF; Celgene Corporation , 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
J Med Chem ; 60(21): 8989-9002, 2017 11 09.
Article em En | MEDLINE | ID: mdl-28991472
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Proteínas Tirosina Quinases / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Inibidores de Proteínas Quinases / Neoplasias de Mama Triplo Negativas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Proteínas Tirosina Quinases / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Inibidores de Proteínas Quinases / Neoplasias de Mama Triplo Negativas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article