Towards global consensus on core outcomes for hidradenitis suppurativa research: an update from the HISTORIC consensus meetings I and II.
Br J Dermatol
; 178(3): 715-721, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29080368
ABSTRACT
BACKGROUND:
A core outcomes set (COS) is an agreed minimum set of outcomes that should be measured and reported in all clinical trials for a specific condition. Hidradenitis suppurativa (HS) has no agreed-upon COS. A central aspect in the COS development process is to identify a set of candidate outcome domains from a long list of items. Our long list had been developed from patient interviews, a systematic review of the literature and a healthcare professional survey, and initial votes had been cast in two e-Delphi surveys. In this manuscript, we describe two in-person consensus meetings of Delphi participants designed to ensure an inclusive approach to generation of domains from related items.OBJECTIVES:
To consider which items from a long list of candidate items to exclude and which to cluster into outcome domains.METHODS:
The study used an international and multistakeholder approach, involving patients, dermatologists, surgeons, the pharmaceutical industry and medical regulators. The study format was a combination of formal presentations, small group work based on nominal group theory and a subsequent online confirmation survey.RESULTS:
Forty-one individuals from 13 countries and four continents participated. Nine items were excluded and there was consensus to propose seven domains disease course, physical signs, HS-specific quality of life, satisfaction, symptoms, pain and global assessments.CONCLUSIONS:
The HISTORIC consensus meetings I and II will be followed by further e-Delphi rounds to finalize the core domain set, building on the work of the in-person consensus meetings.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hidradenite Supurativa
Tipo de estudo:
Guideline
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article