Therapeutic application of extracellular vesicles in kidney disease: promises and challenges.
J Cell Mol Med
; 22(2): 728-737, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29083099
ABSTRACT
Extracellular vesicles (EVs) are nanosized, membrane-bound vesicles released from different cells. Recent studies have revealed that EVs may participate in renal tissue damage and regeneration through mediating inter-nephron communication. Thus, the potential use of EVs as therapeutic vector has gained considerable interest. In this review, we will discuss the basic characteristics of EVs and its role in nephron cellular communication. Then, the application of EVs as therapeutic vector based on its natural content or as carriers of drug, in acute and chronic kidney injury, was discussed. Finally, perspectives and challenges of EVs in therapy of kidney disease were described.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vesículas Extracelulares
/
Nefropatias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article