Development of a Novel Multipenicillin Assay and Assessment of the Impact of Analyte Degradation: Lessons for Scavenged Sampling in Antimicrobial Pharmacokinetic Study Design.

Kipper, Karin; Barker, Charlotte I S; Standing, Joseph F; Sharland, Mike; Johnston, Atholl

Kipper, Karin; Barker, Charlotte I S; Standing, Joseph F; Sharland, Mike; Johnston, Atholl.

Afiliação

Kipper K; Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's University of London, London, United Kingdom karin.kipper@gmail.com.
Barker CIS; University of Tartu, Institute of Chemistry, Tartu, Estonia.
Standing JF; Analytical Services International Ltd., St. George's University of London, London, United Kingdom.
Sharland M; Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's University of London, London, United Kingdom.
Johnston A; Inflammation, Infection and Rheumatology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Antimicrob Agents Chemother ; 62(1)2018 01.

Article em En | MEDLINE | ID: mdl-29084754

Assuntos

Amoxicilina/sangue; Ampicilina/sangue; Antibacterianos/sangue; Floxacilina/sangue; Penicilina G/sangue; Piperacilina/sangue; Cromatografia Líquida de Alta Pressão; Estabilidade de Medicamentos; Humanos; Espectrometria de Massas em Tandem

Palavras-chave

beta-lactams; drug stability; high-pressure liquid chromatography; mass spectrometry; penicillins; pharmacokinetics; scavenged sampling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Penicilina G / Piperacilina / Floxacilina / Amoxicilina / Ampicilina / Antibacterianos Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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