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DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway.
Bai, Juli; Cervantes, Christopher; Liu, Juan; He, Sijia; Zhou, Haiyan; Zhang, Bilin; Cai, Huan; Yin, Dongqing; Hu, Derong; Li, Zhi; Chen, Hongzhi; Gao, Xiaoli; Wang, Fang; O'Connor, Jason C; Xu, Yong; Liu, Meilian; Dong, Lily Q; Liu, Feng.
Afiliação
  • Bai J; Department of Metabolism and Endocrinology, Metabolic Syndrome Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
  • Cervantes C; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • Liu J; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • He S; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • Zhou H; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • Zhang B; Department of Metabolism and Endocrinology, Metabolic Syndrome Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
  • Cai H; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • Yin D; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • Hu D; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • Li Z; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • Chen H; Department of Metabolism and Endocrinology, Metabolic Syndrome Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
  • Gao X; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • Wang F; Department of Metabolism and Endocrinology, Metabolic Syndrome Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
  • O'Connor JC; Department of Biochemistry, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • Xu Y; Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
  • Liu M; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229.
  • Dong LQ; Audie L. Murphy Memorial VA Hospital, South Texas Veterans Health Care System, San Antonio, TX 78229.
  • Liu F; Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Proc Natl Acad Sci U S A ; 114(46): 12196-12201, 2017 11 14.
Article em En | MEDLINE | ID: mdl-29087318
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Resistência à Insulina / Glutationa Transferase / Proteínas de Membrana / Nucleotidiltransferases / Obesidade Tipo de estudo: Etiology_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Resistência à Insulina / Glutationa Transferase / Proteínas de Membrana / Nucleotidiltransferases / Obesidade Tipo de estudo: Etiology_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article