[BIOLOGICALLY ACTIVE ALKALOIDS FROM RHIZOMES WITH ROOTS OF VINCA HERBACEA WALDST. ET KIT, GROWING IN GEORGIA].
Georgian Med News
; (271): 122-127, 2017 Oct.
Article
em Ru
| MEDLINE
| ID: mdl-29099714
ABSTRACT
Roots and rhizomes of Vinca herbacea Waldst. et Kit, were collected during early flowering and fruiting. Ð henophases biologically active substances I and II were obtained by liquid-liquid extraction. Dominant alkaloids tabersonin, reserpine, maidine, norfluorocurarin and copsinin were obtained after the dispertion in citrare-phosfhate buffer and subsequent TLC. Accelerated restitution of granulocytopoiesis was observed in mice during both irradiation and myelotoxic drug-induced acute leucopenia. Increase in total WBC over 200% was observed after treatment by substance I in drug-induced leucopenia model (fivefold oral administration) and over 130% after treatment by substance I in irradiate mice (fivefold intraperitoneal administration). Morphological and anatomical structures of the underground organs of V. herbacea have been studied. The main microstructural characteristics are revealed - Rhizomes are characterized by coutinized epidermis, lamellar collenchyma, fibers and the texture of the vascular system of a monocyclic structure. The root system shows the whole cortex, the endoderm with Kaspar spots; the outer, radially continuous phloem tissue is located in the conducting system and distinguishes the cylindrical xylem tissue with annular and spiral-circular blood vessels.
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Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Vinca
/
Vinca
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
País/Região como assunto:
Europa
Idioma:
Ru
Ano de publicação:
2017
Tipo de documento:
Article