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Total Synthesis of (+)-Medicarpin.
Yang, Xiaoming; Zhao, Yu; Hsieh, Min-Tsang; Xin, Guang; Wu, Rong-Tsun; Hsu, Pei-Lun; Horng, Lin-Yea; Sung, Hui-Ching; Cheng, Chien-Hsin; Lee, Kuo-Hsiung.
Afiliação
  • Yang X; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
  • Zhao Y; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
  • Hsieh MT; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
  • Xin G; Chinese Medicine Research and Development Center, China Medical University and Hospital , Taichung 40402, Taiwan.
  • Wu RT; School of Pharmacy, China Medical University , Taichung 404, Taiwan.
  • Hsu PL; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
  • Horng LY; Research Center for Drug Discovery, National Yang-Ming University , Taipei 112, Taiwan.
  • Sung HC; Research Center for Drug Discovery, National Yang-Ming University , Taipei 112, Taiwan.
  • Cheng CH; Research Center for Drug Discovery, National Yang-Ming University , Taipei 112, Taiwan.
  • Lee KH; Research Center for Drug Discovery, National Yang-Ming University , Taipei 112, Taiwan.
J Nat Prod ; 80(12): 3284-3288, 2017 12 22.
Article em En | MEDLINE | ID: mdl-29164880
(+)-Medicarpin has been synthesized asymmetrically for the first time in a linear scalable process with an overall yield of 11%. The two chiral centers were constructed in one step via condensation using a chiral oxazolidinone auxiliary. This method will likely accelerate research on medicarpin as an erythropoietin inducer for erythropoietin-deficient diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pterocarpanos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pterocarpanos Idioma: En Ano de publicação: 2017 Tipo de documento: Article