Inhibitory effects of (+)-spectaline and iso-6-spectaline from Senna spectabilis on the growth and ultrastructure of human-infective species Trypanosoma brucei rhodesiense bloodstream form.

Lim, Kah Tee; Amanah, Azimah; Chear, Nelson Jeng-Yeou; Zahari, Zuriati; Zainuddin, Zafarina; Adenan, Mohd Ilham

Lim, Kah Tee; Amanah, Azimah; Chear, Nelson Jeng-Yeou; Zahari, Zuriati; Zainuddin, Zafarina; Adenan, Mohd Ilham.

Afiliação

Lim KT; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Blok 5-A, Halaman Bukit Gambir, 11700 Penang, Malaysia.
Amanah A; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Blok 5-A, Halaman Bukit Gambir, 11700 Penang, Malaysia.
Chear NJ; Centre for Drug Research (CDR), Universiti Sains Malaysia, 11800 Penang, Malaysia.
Zahari Z; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Blok 5-A, Halaman Bukit Gambir, 11700 Penang, Malaysia.
Zainuddin Z; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Blok 5-A, Halaman Bukit Gambir, 11700 Penang, Malaysia; Analytical Biochemistry Research Centre (ABrC), Universiti Sains Malaysia, 11800
Adenan MI; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Blok 5-A, Halaman Bukit Gambir, 11700 Penang, Malaysia; Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor

Exp Parasitol ; 184: 57-66, 2018 Jan.

Article em En | MEDLINE | ID: mdl-29175017

Assuntos

Piperidinas/farmacologia; Senna/química; Tripanossomicidas/farmacologia; Trypanosoma brucei rhodesiense/efeitos dos fármacos; Animais; Bioensaio; Espectroscopia de Ressonância Magnética Nuclear de Carbono-13; Linhagem Celular; Humanos; Concentração Inibidora 50; Microscopia Eletrônica de Varredura; Microscopia Eletrônica de Transmissão; Mioblastos Esqueléticos/efeitos dos fármacos; Piperidinas/isolamento & purificação; Piperidinas/toxicidade; Extratos Vegetais/isolamento & purificação; Extratos Vegetais/farmacologia; Extratos Vegetais/toxicidade; Folhas de Planta/química; Espectroscopia de Prótons por Ressonância Magnética; Ratos; Senna/classificação; Tripanossomicidas/isolamento & purificação; Tripanossomicidas/toxicidade; Trypanosoma brucei rhodesiense/crescimento & desenvolvimento; Trypanosoma brucei rhodesiense/ultraestrutura

Palavras-chave

(+)-spectaline; Autophagy; Iso-6-spectaline; Piperidine alkaloids; Senna spectabilis; Tyrpanosoma brucei rhodesiense

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Tripanossomicidas / Trypanosoma brucei rhodesiense / Senna Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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