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Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism.
Tanner, Julie-Anne; Zhu, Andy Z; Claw, Katrina G; Prasad, Bhagwat; Korchina, Viktoriya; Hu, Jianhong; Doddapaneni, HarshaVardhan; Muzny, Donna M; Schuetz, Erin G; Lerman, Caryn; Thummel, Kenneth E; Scherer, Steven E; Tyndale, Rachel F.
Afiliação
  • Tanner JA; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH).
  • Zhu AZ; Department of Pharmacology and Toxicology.
  • Claw KG; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH).
  • Prasad B; Department of Pharmacology and Toxicology.
  • Korchina V; Department of Pharmaceutics, University of Washington, Seattle, Washington.
  • Hu J; Department of Pharmaceutics, University of Washington, Seattle, Washington.
  • Doddapaneni H; Department of Molecular and Human Genetics, The Baylor College of Medicine Human Genome Sequencing Center, Houston, Texas, USA.
  • Muzny DM; Department of Molecular and Human Genetics, The Baylor College of Medicine Human Genome Sequencing Center, Houston, Texas, USA.
  • Schuetz EG; Department of Molecular and Human Genetics, The Baylor College of Medicine Human Genome Sequencing Center, Houston, Texas, USA.
  • Lerman C; Department of Molecular and Human Genetics, The Baylor College of Medicine Human Genome Sequencing Center, Houston, Texas, USA.
  • Thummel KE; Pharmaceutical Sciences Department, St Jude Children's Research Hospital, Memphis, Tennessee.
  • Scherer SE; Department of Psychiatry, Annenberg School for Communication, and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Tyndale RF; Department of Pharmaceutics, University of Washington, Seattle, Washington.
Pharmacogenet Genomics ; 28(1): 7-16, 2018 Jan.
Article em En | MEDLINE | ID: mdl-29232328
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise de Sequência de DNA / Polimorfismo de Nucleotídeo Único / Sequenciamento de Nucleotídeos em Larga Escala / Citocromo P-450 CYP2A6 / Nicotina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise de Sequência de DNA / Polimorfismo de Nucleotídeo Único / Sequenciamento de Nucleotídeos em Larga Escala / Citocromo P-450 CYP2A6 / Nicotina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article