Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-<sup>13</sup>C] Lactate.

Tee, Sui Seng; Suster, Izabela; Truong, Steven; Jeong, Sangmoo; Eskandari, Roozbeh; DiGialleonardo, Valentina; Alvarez, Julio A; Aldeborgh, Hannah N; Keshari, Kayvan R

Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-¹³C] Lactate.

Tee, Sui Seng; Suster, Izabela; Truong, Steven; Jeong, Sangmoo; Eskandari, Roozbeh; DiGialleonardo, Valentina; Alvarez, Julio A; Aldeborgh, Hannah N; Keshari, Kayvan R.

Afiliação

Tee SS; Department of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Suster I; Department of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Truong S; Hunter College, New York, New York.
Jeong S; Department of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Eskandari R; Department of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
DiGialleonardo V; Department of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Alvarez JA; Weill Cornell Medical College, New York, New York.
Aldeborgh HN; Department of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Keshari KR; Department of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York. rahimikk@mskcc.org.

Mol Cancer Res ; 16(3): 453-460, 2018 03.

Article em En | MEDLINE | ID: mdl-29330287

Assuntos

Ácido Láctico/metabolismo; Neoplasias da Próstata/tratamento farmacológico; Neoplasias da Próstata/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Glicólise/efeitos dos fármacos; Compostos Heterocíclicos com 3 Anéis/farmacologia; Humanos; Masculino; Terapia de Alvo Molecular; PTEN Fosfo-Hidrolase/genética; PTEN Fosfo-Hidrolase/metabolismo; Neoplasias da Próstata/patologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Esferoides Celulares

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Ácido Láctico / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt Limite: Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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