Structural basis for DNMT3A-mediated de novo DNA methylation.

Zhang, Zhi-Min; Lu, Rui; Wang, Pengcheng; Yu, Yang; Chen, Dongliang; Gao, Linfeng; Liu, Shuo; Ji, Debin; Rothbart, Scott B; Wang, Yinsheng; Wang, Gang Greg; Song, Jikui

Zhang, Zhi-Min; Lu, Rui; Wang, Pengcheng; Yu, Yang; Chen, Dongliang; Gao, Linfeng; Liu, Shuo; Ji, Debin; Rothbart, Scott B; Wang, Yinsheng; Wang, Gang Greg; Song, Jikui.

Afiliação

Zhang ZM; Department of Biochemistry, University of California, Riverside, California 92521, USA.
Lu R; The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.
Wang P; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.
Yu Y; Environmental Toxicology Graduate Program, University of California, Riverside, California 92521, USA.
Chen D; Environmental Toxicology Graduate Program, University of California, Riverside, California 92521, USA.
Gao L; The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.
Liu S; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.
Ji D; Environmental Toxicology Graduate Program, University of California, Riverside, California 92521, USA.
Rothbart SB; Environmental Toxicology Graduate Program, University of California, Riverside, California 92521, USA.
Wang Y; Department of Chemistry, University of California, Riverside, California 92521, USA.
Wang GG; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.
Song J; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA.

Nature ; 554(7692): 387-391, 2018 02 15.

Article em En | MEDLINE | ID: mdl-29414941

Assuntos

DNA (Citosina-5-)-Metiltransferases/química; DNA (Citosina-5-)-Metiltransferases/metabolismo; Metilação de DNA; DNA/química; DNA/metabolismo; Sítios de Ligação; Proliferação de Células; Ilhas de CpG/genética; Cristalografia por Raios X; DNA/genética; DNA (Citosina-5-)-Metiltransferases/genética; Metilação de DNA/genética; DNA Metiltransferase 3A; Proteínas de Ligação a DNA/química; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Neoplasias Hematológicas/enzimologia; Neoplasias Hematológicas/genética; Neoplasias Hematológicas/patologia; Humanos; Modelos Moleculares; Mutação; Ligação Proteica; Domínios Proteicos; Relação Estrutura-Atividade; Especificidade por Substrato

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA / Metilação de DNA / DNA (Citosina-5-)-Metiltransferases Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google