Dynamic Protein-Metal Ion Networks: A Unique Approach to Injectable and Self-Healable Metal Sulfide/Protein Hybrid Hydrogels with High Photothermal Efficiency.
Chemistry
; 24(25): 6557-6563, 2018 May 02.
Article
em En
| MEDLINE
| ID: mdl-29417640
ABSTRACT
A new strategy is proposed to fabricate adaptable protein-based hydrogel networks with both injectable and self-healable properties. By mixing proteins and metal ions under alkaline conditions, the metal ions can crosslink proteins into protein-metal ion dynamic networks. Subsequently, the metal ions can react with the cysteine residues of protein to in situ form corresponding metal sulfide NPs with ultra-small size, which leads to nanocomposite hydrogels with adaptable structures. This approach is general and a series of metal sulfide NP in situ embedded nanocomposite hydrogels were obtained. As an example, a Bi2 S3 -BSA hydrogel with tunable networks is shown to serve as an injectable, self-healable photothermal agent for the treatment of tumors. Our finding paves a new avenue for the preparation of injectable and self-healable hydrogels with potential applications in biomedicine.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfetos
/
Proteínas
/
Hidrogéis
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article