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A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence.
Mamedov, Murad R; Scholzen, Anja; Nair, Ramesh V; Cumnock, Katherine; Kenkel, Justin A; Oliveira, Jose Henrique M; Trujillo, Damian L; Saligrama, Naresha; Zhang, Yue; Rubelt, Florian; Schneider, David S; Chien, Yueh-Hsiu; Sauerwein, Robert W; Davis, Mark M.
Afiliação
  • Mamedov MR; Program in Immunology, Stanford University, Stanford, CA 94305, USA; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.
  • Scholzen A; Department of Medical Microbiology, Radboud University Medical Center, 6500 HB, Nijmegen, the Netherlands; Innatoss Laboratories B.V., 5349 AB Oss, the Netherlands.
  • Nair RV; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
  • Cumnock K; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
  • Kenkel JA; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Oliveira JHM; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, Brazil.
  • Trujillo DL; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Aduro Biotech, Inc., Berkeley, CA 94710, USA.
  • Saligrama N; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
  • Zhang Y; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Genetics Bioinformatics Service Center, Stanford University, Stanford, CA 94305, USA.
  • Rubelt F; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
  • Schneider DS; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
  • Chien YH; Program in Immunology, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
  • Sauerwein RW; Department of Medical Microbiology, Radboud University Medical Center, 6500 HB, Nijmegen, the Netherlands.
  • Davis MM; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: mmdavis@sta
Immunity ; 48(2): 350-363.e7, 2018 02 20.
Article em En | MEDLINE | ID: mdl-29426701
ABSTRACT
Despite evidence that γδ T cells play an important role during malaria, their precise role remains unclear. During murine malaria induced by Plasmodium chabaudi infection and in human P. falciparum infection, we found that γδ T cells expanded rapidly after resolution of acute parasitemia, in contrast to αß T cells that expanded at the acute stage and then declined. Single-cell sequencing showed that TRAV15N-1 (Vδ6.3) γδ T cells were clonally expanded in mice and had convergent complementarity-determining region 3 sequences. These γδ T cells expressed specific cytokines, M-CSF, CCL5, CCL3, which are known to act on myeloid cells, indicating that this γδ T cell subset might have distinct functions. Both γδ T cells and M-CSF were necessary for preventing parasitemic recurrence. These findings point to an M-CSF-producing γδ T cell subset that fulfills a specialized protective role in the later stage of malaria infection when αß T cells have declined.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Subpopulações de Linfócitos T / Fator Estimulador de Colônias de Macrófagos / Receptores de Antígenos de Linfócitos T gama-delta / Malária Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Subpopulações de Linfócitos T / Fator Estimulador de Colônias de Macrófagos / Receptores de Antígenos de Linfócitos T gama-delta / Malária Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article