Phase I study of an active immunotherapy for asymptomatic phase Lymphoplasmacytic lymphoma with DNA vaccines encoding antigen-chemokine fusion: study protocol.

Thomas, Sheeba K; Cha, Soung-Chul; Smith, D Lynne; Kim, Kun Hwa; Parshottam, Sapna R; Rao, Sheetal; Popescu, Michael; Lee, Vincent Y; Neelapu, Sattva S; Kwak, Larry W

Thomas, Sheeba K; Cha, Soung-Chul; Smith, D Lynne; Kim, Kun Hwa; Parshottam, Sapna R; Rao, Sheetal; Popescu, Michael; Lee, Vincent Y; Neelapu, Sattva S; Kwak, Larry W.

Afiliação

Thomas SK; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Cha SC; Toni Stephenson Lymphoma Center, Department of Hematology and Hematopoietic Stem Cell Transplantation, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.
Smith DL; Toni Stephenson Lymphoma Center, Department of Hematology and Hematopoietic Stem Cell Transplantation, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.
Kim KH; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Parshottam SR; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Rao S; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Popescu M; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Lee VY; Toni Stephenson Lymphoma Center, Department of Hematology and Hematopoietic Stem Cell Transplantation, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.
Neelapu SS; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Kwak LW; Toni Stephenson Lymphoma Center, Department of Hematology and Hematopoietic Stem Cell Transplantation, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA. lkwak@coh.org.

BMC Cancer ; 18(1): 187, 2018 02 13.

Article em En | MEDLINE | ID: mdl-29439670

Assuntos

Imunoterapia Ativa/métodos; Proteínas Recombinantes de Fusão/uso terapêutico; Vacinas de DNA/uso terapêutico; Macroglobulinemia de Waldenstrom/terapia; Adulto; Idoso; Antígenos/genética; Antígenos/imunologia; Antígenos/metabolismo; Quimiocina CCL20/genética; Quimiocina CCL20/imunologia; Quimiocina CCL20/metabolismo; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Avaliação de Resultados em Cuidados de Saúde; Estudos Prospectivos; Proteínas Recombinantes de Fusão/imunologia; Vacinação/métodos; Vacinas de DNA/imunologia; Macroglobulinemia de Waldenstrom/imunologia; Macroglobulinemia de Waldenstrom/patologia

Palavras-chave

DNA vaccine; Idiotype; Immune response; Lymphoma; Personalized medicine; Phase I

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Imunoterapia Ativa / Macroglobulinemia de Waldenstrom / Vacinas de DNA Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google