Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis.

Luchetti, Sabina; Fransen, Nina L; van Eden, Corbert G; Ramaglia, Valeria; Mason, Matthew; Huitinga, Inge

Luchetti, Sabina; Fransen, Nina L; van Eden, Corbert G; Ramaglia, Valeria; Mason, Matthew; Huitinga, Inge.

Afiliação

Luchetti S; Laboratory of Neuroimmunology, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.
Fransen NL; Laboratory of Neuroimmunology, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.
van Eden CG; Laboratory of Neuroimmunology, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.
Ramaglia V; Laboratory of Neuroimmunology, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.
Mason M; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Huitinga I; Laboratory of Neuroimmunology, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.

Acta Neuropathol ; 135(4): 511-528, 2018 04.

Article em En | MEDLINE | ID: mdl-29441412

Assuntos

Encéfalo/patologia; Esclerose Múltipla Crônica Progressiva/patologia; Caracteres Sexuais; Idoso; Encéfalo/metabolismo; Proteínas de Ligação a DNA/metabolismo; Progressão da Doença; Feminino; Antígenos HLA/metabolismo; Humanos; Masculino; Pessoa de Meia-Idade; Esclerose Múltipla Crônica Progressiva/metabolismo; Estudos Retrospectivos; Índice de Gravidade de Doença; Fatores de Transcrição/metabolismo

Palavras-chave

Chronic active lesions; Lesion activity; Multiple sclerosis; Neuropathology; Remyelination; Sex characteristics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Caracteres Sexuais / Esclerose Múltipla Crônica Progressiva Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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