Acute effect of bisphenol A: Signaling pathways on calcium influx in immature rat testes.
Reprod Toxicol
; 77: 94-102, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29476780
ABSTRACT
We investigated the acute effect of low concentrations of BPA on calcium influx and the mechanism of action of BPA in this rapid response in the rat testis. BPA increased calcium influx at 1 pM and 1â¯nM at 300â¯s of incubation, in a similar manner to that of estradiol. At 1 pM, BPA stimulated calcium influx independently of classical estrogen receptors, consistent with a G-protein coupled receptor. This effect also involves the modulation of ionic channels, such as K+, TRPV1 and Cl- channels. Furthermore, BPA is able to modulate calcium from intracellular storages by inhibiting SERCA and activating IP3 receptor/Ca2+ channels at the endoplasmic reticulum and activate kinase proteins, such as PKA and PKC. The rapid responses of BPA on calcium influx could, in turn, trigger a cross talk by MEK and p38MAPK activation and also mediate genomic responses.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fenóis
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Testículo
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Compostos Benzidrílicos
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Cálcio
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Disruptores Endócrinos
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article