Partial exposure of frog heart to high-potassium solution: an easily reproducible model mimicking ST segment changes.
J Vet Med Sci
; 80(4): 578-582, 2018 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-29503350
ABSTRACT
By simply inducing burn injuries on the bullfrog heart, we previously reported a simple model of abnormal ST segment changes observed in human ischemic heart disease. In the present study, instead of inducing burn injuries, we partially exposed the surface of the frog heart to high-potassium (K+) solution to create a concentration gradient of the extracellular K+ within the myocardium. Dual recordings of ECG and the cardiac action potential demonstrated significant elevation of the ST segment and the resting membrane potential, indicating its usefulness as a simple model of heart injury. Additionally, from our results, Na+/K+-ATPase activity was thought to be primarily responsible for generating the K+ concentration gradient and inducing the ST segment changes in ECG.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
/
Potássio
/
Coração
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article