HLA-DQB1*03 and DRB1*07 alleles increase the risk of cervical cancer among Uighur and Han women in Xinjiang, China.
Future Oncol
; 14(20): 2005-2011, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29513033
ABSTRACT
AIM:
To explore the association between the determinant factors including HLA-DQB1*03, DRB1-*07, -*13 and high-risk HPV infection, the cervical squamous cell carcinoma (CSCC) pathogenesis among Chinese Uighur and Han population. MATERIALS &METHODS:
HLA alleles were genotyped by PCR sequence-specific primers.RESULTS:
HPV16 infection rate was significantly higher among the Uighurs and Hans with CSCC as compared with healthy controls, respectively. HLA-DQB1*03 significantly increased among Uighurs with CSCC, while HLA-DRB1*07 significantly increased among Hans with CSCC. Similar tendencies were observed for DQB1*03 with HPV16-positive Uighurs CSCC and DRB1*07 with HPV16-positive Hans CSCC.CONCLUSION:
This study suggests that HLA-DQB1*03 and DRB1*07 alleles may influence the immune response to HPV16 infection and increase the risk of CSCC among the Uighurs and Hans in China.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Etnicidade
/
Neoplasias do Colo do Útero
/
Predisposição Genética para Doença
/
Alelos
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Cadeias beta de HLA-DQ
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article