Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD.

Yang, Mingxing; Kohler, Maxie; Heyder, Tina; Forsslund, Helena; Garberg, Hilde K; Karimi, Reza; Grunewald, Johan; Berven, Frode S; Magnus Sköld, C; Wheelock, Åsa M

Yang, Mingxing; Kohler, Maxie; Heyder, Tina; Forsslund, Helena; Garberg, Hilde K; Karimi, Reza; Grunewald, Johan; Berven, Frode S; Magnus Sköld, C; Wheelock, Åsa M.

Afiliação

Yang M; Department of Medicine Solna & Center for Molecular Medicine, Respiratory Medicine Unit, Lung Research Lab L4:01, Karolinska Institutet, 171 76, Stockholm, Sweden. 2002ymx02@gmail.com.
Kohler M; Department of Medicine Solna & Center for Molecular Medicine, Respiratory Medicine Unit, Lung Research Lab L4:01, Karolinska Institutet, 171 76, Stockholm, Sweden.
Heyder T; Department of Medicine Solna & Center for Molecular Medicine, Respiratory Medicine Unit, Lung Research Lab L4:01, Karolinska Institutet, 171 76, Stockholm, Sweden.
Forsslund H; Department of Medicine Solna & Center for Molecular Medicine, Respiratory Medicine Unit, Lung Research Lab L4:01, Karolinska Institutet, 171 76, Stockholm, Sweden.
Garberg HK; Department of Biomedicine, Proteomics Unit (PROBE), University of Bergen, Bergen, Norway.
Karimi R; Department of Medicine Solna & Center for Molecular Medicine, Respiratory Medicine Unit, Lung Research Lab L4:01, Karolinska Institutet, 171 76, Stockholm, Sweden.
Grunewald J; Department of Medicine Solna & Center for Molecular Medicine, Respiratory Medicine Unit, Lung Research Lab L4:01, Karolinska Institutet, 171 76, Stockholm, Sweden.
Berven FS; Department of Biomedicine, Proteomics Unit (PROBE), University of Bergen, Bergen, Norway.
Magnus Sköld C; Department of Medicine Solna & Center for Molecular Medicine, Respiratory Medicine Unit, Lung Research Lab L4:01, Karolinska Institutet, 171 76, Stockholm, Sweden.
Wheelock ÅM; Department of Medicine Solna & Center for Molecular Medicine, Respiratory Medicine Unit, Lung Research Lab L4:01, Karolinska Institutet, 171 76, Stockholm, Sweden. asa.wheelock@ki.se.

Respir Res ; 19(1): 40, 2018 03 08.

Article em En | MEDLINE | ID: mdl-29514648

Assuntos

Líquido da Lavagem Broncoalveolar; Proteoma/genética; Doença Pulmonar Obstrutiva Crônica/genética; Fumantes; Fumar/genética; Espirometria/tendências; Idoso; Líquido da Lavagem Broncoalveolar/citologia; Estudos de Coortes; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Doença Pulmonar Obstrutiva Crônica/diagnóstico; Doença Pulmonar Obstrutiva Crônica/fisiopatologia; Fumar/fisiopatologia; Fatores de Tempo

Palavras-chave

Bronchoalveolar lavage; COPD; Inflammation; Proteomics; Smoking

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espirometria / Líquido da Lavagem Broncoalveolar / Fumar / Proteoma / Doença Pulmonar Obstrutiva Crônica / Fumantes Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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