Impacts of maturation on the micromechanics of the meniscus extracellular matrix.
J Biomech
; 72: 252-257, 2018 04 27.
Article
em En
| MEDLINE
| ID: mdl-29555076
ABSTRACT
To elucidate how maturation impacts the structure and mechanics of meniscus extracellular matrix (ECM) at the length scale of collagen fibrils and fibers, we tested the micromechanical properties of fetal and adult bovine menisci via atomic force microscopy (AFM)-nanoindentation. For circumferential fibers, we detected significant increase in the effective indentation modulus, Eind, with age. Such impact is in agreement with the increase in collagen fibril diameter and alignment during maturation, and is more pronounced in the outer zone, where collagen fibrils are more aligned and packed. Meanwhile, maturation also markedly increases the Eind of radial tie fibers, but not those of intact surface or superficial layer. These results provide new insights into the effect of maturation on the assembly of meniscus ECM, and enable the design of new meniscus repair strategies by modulating local ECM structure and mechanical behaviors.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colágenos Fibrilares
/
Matriz Extracelular
/
Menisco
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article