Mitochondria-ER Pas de Deux Controls Memory T Cell Function.
Immunity
; 48(3): 479-481, 2018 03 20.
Article
em En
| MEDLINE
| ID: mdl-29562198
ABSTRACT
Memory CD8+ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3ß signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8+ T cells to produce IFN-γ.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interferon gama
/
Linfócitos T CD8-Positivos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article