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Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis.
Xu, He; Lee, Min-Sik; Tsai, Pei-Yun; Adler, Ashley S; Curry, Natasha L; Challa, Saketh; Freinkman, Elizaveta; Hitchcock, Daniel S; Copps, Kyle D; White, Morris F; Bronson, Roderick T; Marcotrigiano, Michael; Wu, Yaotang; Clish, Clary B; Kalaany, Nada Y.
Afiliação
  • Xu H; Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115.
  • Lee MS; Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
  • Tsai PY; Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115.
  • Adler AS; Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
  • Curry NL; Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115.
  • Challa S; Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
  • Freinkman E; Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115.
  • Hitchcock DS; Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115.
  • Copps KD; Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115.
  • White MF; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
  • Bronson RT; Broad Institute of MIT and Harvard, Cambridge, MA 02142.
  • Marcotrigiano M; Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115.
  • Wu Y; Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
  • Clish CB; Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115.
  • Kalaany NY; Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
Proc Natl Acad Sci U S A ; 115(16): 4228-4233, 2018 04 17.
Article em En | MEDLINE | ID: mdl-29610318
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Proteínas Proto-Oncogênicas p21(ras) / Genes ras / Carcinoma Pulmonar de Células não Pequenas / Proteínas Substratos do Receptor de Insulina / Carcinogênese / Insulina / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Proteínas Proto-Oncogênicas p21(ras) / Genes ras / Carcinoma Pulmonar de Células não Pequenas / Proteínas Substratos do Receptor de Insulina / Carcinogênese / Insulina / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article