The S230R Integrase Substitution Associated With Virus Load Rebound During Dolutegravir Monotherapy Confers Low-Level Resistance to Integrase Strand-Transfer Inhibitors.

Pham, Hanh T; Labrie, Lydia; Wijting, Ingeborg E A; Hassounah, Said; Lok, Ka Yee; Portna, Inna; Goring, Mark E; Han, Yingshan; Lungu, Cynthia; van der Ende, Marchina E; Brenner, Bluma G; Boucher, Charles A; Rijnders, Bart J A; van Kampen, Jeroen J A; Mesplède, Thibault; Wainberg, Mark A

Pham, Hanh T; Labrie, Lydia; Wijting, Ingeborg E A; Hassounah, Said; Lok, Ka Yee; Portna, Inna; Goring, Mark E; Han, Yingshan; Lungu, Cynthia; van der Ende, Marchina E; Brenner, Bluma G; Boucher, Charles A; Rijnders, Bart J A; van Kampen, Jeroen J A; Mesplède, Thibault; Wainberg, Mark A.

Afiliação

Pham HT; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Labrie L; Department of Microbiology and Immunology, McGill University, Montreal, Canada.
Wijting IEA; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Hassounah S; Department of Microbiology and Immunology, McGill University, Montreal, Canada.
Lok KY; Department of Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, Netherlands.
Portna I; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Goring ME; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Canada.
Han Y; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Lungu C; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
van der Ende ME; Department of Microbiology and Immunology, McGill University, Montreal, Canada.
Brenner BG; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
Boucher CA; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Canada.
Rijnders BJA; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
van Kampen JJA; Department of Viroscience, Erasmus University, Rotterdam, Netherlands.
Mesplède T; Department of Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, Netherlands.
Wainberg MA; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.

J Infect Dis ; 218(5): 698-706, 2018 07 24.

Article em En | MEDLINE | ID: mdl-29617824

Assuntos

Substituição de Aminoácidos; Farmacorresistência Viral; Infecções por HIV/tratamento farmacológico; Inibidores de Integrase de HIV/uso terapêutico; HIV/efeitos dos fármacos; Compostos Heterocíclicos com 3 Anéis/uso terapêutico; Carga Viral; HIV/genética; HIV/crescimento & desenvolvimento; HIV/isolamento & purificação; Integrase de HIV/genética; Integrase de HIV/metabolismo; Humanos; Quimioterapia de Manutenção/métodos; Testes de Sensibilidade Microbiana; Mutação de Sentido Incorreto; Oxazinas; Piperazinas; Piridonas; Falha de Tratamento; Replicação Viral

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV / Inibidores de Integrase de HIV / Carga Viral / Substituição de Aminoácidos / Farmacorresistência Viral / Compostos Heterocíclicos com 3 Anéis Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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