Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal.

Weigand, Tim; Singler, Benjamin; Fleming, Thomas; Nawroth, Peter; Klika, Karel D; Thiel, Christian; Baelde, Hans; Garbade, Sven F; Wagner, Andreas H; Hecker, Markus; Yard, Benito A; Amberger, Albert; Zschocke, Johannes; Schmitt, Claus P; Peters, Verena

Weigand, Tim; Singler, Benjamin; Fleming, Thomas; Nawroth, Peter; Klika, Karel D; Thiel, Christian; Baelde, Hans; Garbade, Sven F; Wagner, Andreas H; Hecker, Markus; Yard, Benito A; Amberger, Albert; Zschocke, Johannes; Schmitt, Claus P; Peters, Verena.

Afiliação

Weigand T; Centre for Paediatric and Adolescent Medicine, University Hospital of Heidelberg, Heidelberg, Germany.
Singler B; Centre for Paediatric and Adolescent Medicine, University Hospital of Heidelberg, Heidelberg, Germany.
Fleming T; Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, Heidelberg, Germany.
Nawroth P; Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, Heidelberg, Germany.
Klika KD; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Thiel C; Institute for Diabetes and Cancer IDC Helmholtz Center Munich, Germany & Joint Heidelberg-IDC Translational Diabetes Program, Neuherberg, Germany.
Baelde H; Core Facility, Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Garbade SF; Centre for Paediatric and Adolescent Medicine, University Hospital of Heidelberg, Heidelberg, Germany.
Wagner AH; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Hecker M; Centre for Paediatric and Adolescent Medicine, University Hospital of Heidelberg, Heidelberg, Germany.
Yard BA; Department of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany.
Amberger A; Department of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany.
Zschocke J; Department of Nephrology, Endocrinology and Rheumatology, Fifth Department of Medicine, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.
Schmitt CP; Division of Human Genetics, Medical University Innsbruck, Innsbruck, Austria.
Peters V; Division of Human Genetics, Medical University Innsbruck, Innsbruck, Austria.

Cell Physiol Biochem ; 46(2): 713-726, 2018.

Article em En | MEDLINE | ID: mdl-29621776

Assuntos

Carnosina/química; Carnosina/metabolismo; Polímeros/química; Aldeído Pirúvico/química; Animais; Anserina/análise; Anserina/química; Anserina/metabolismo; Carnosina/análise; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Cromatografia Líquida de Alta Pressão; Glutationa/análise; Glutationa Peroxidase/genética; Glutationa Peroxidase/metabolismo; Produtos Finais de Glicação Avançada/química; Produtos Finais de Glicação Avançada/metabolismo; Humanos; Glicoproteínas de Membrana/metabolismo; Proteínas de Membrana Transportadoras/metabolismo; Camundongos; Estresse Oxidativo/efeitos dos fármacos; Transportador 1 de Peptídeos/genética; Transportador 1 de Peptídeos/metabolismo; Podócitos/citologia; Podócitos/efeitos dos fármacos; Podócitos/metabolismo; Polímeros/metabolismo; Aldeído Pirúvico/toxicidade; Albumina Sérica/química; Superóxido Dismutase/genética; Superóxido Dismutase/metabolismo; Simportadores/genética; Simportadores/metabolismo

Palavras-chave

Anserine; Carnosine; Diabetic nephropathy; Methylglyoxal; Renal cells; Taurine transporter

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Aldeído Pirúvico / Carnosina Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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