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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M; Zhao, Wei; Robertson, Neil R; Chu, Audrey Y; Gan, Wei; Kitajima, Hidetoshi; Taliun, Daniel; Rayner, N William; Guo, Xiuqing; Lu, Yingchang; Li, Man; Jensen, Richard A; Hu, Yao; Huo, Shaofeng; Lohman, Kurt K; Zhang, Weihua; Cook, James P; Prins, Bram Peter; Flannick, Jason; Grarup, Niels; Trubetskoy, Vassily Vladimirovich; Kravic, Jasmina; Kim, Young Jin; Rybin, Denis V; Yaghootkar, Hanieh; Müller-Nurasyid, Martina; Meidtner, Karina; Li-Gao, Ruifang; Varga, Tibor V; Marten, Jonathan; Li, Jin; Smith, Albert Vernon; An, Ping; Ligthart, Symen; Gustafsson, Stefan; Malerba, Giovanni; Demirkan, Ayse; Tajes, Juan Fernandez; Steinthorsdottir, Valgerdur; Wuttke, Matthias; Lecoeur, Cécile; Preuss, Michael; Bielak, Lawrence F; Graff, Marielisa; Highland, Heather M; Justice, Anne E; Liu, Dajiang J; Marouli, Eirini.
Afiliação
  • Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. anubha@well.ox.ac.uk.
  • Wessel J; Departments of Epidemiology and Medicine, Diabetes Translational Research Center, Indiana University, Indianapolis, IN, USA.
  • Willems SM; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Zhao W; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.
  • Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Chu AY; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Gan W; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
  • Kitajima H; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Taliun D; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Rayner NW; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Guo X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Lu Y; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Li M; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Jensen RA; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
  • Hu Y; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Huo S; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Lohman KK; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Zhang W; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Cook JP; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
  • Prins BP; Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China.
  • Flannick J; Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China.
  • Grarup N; Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
  • Trubetskoy VV; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Kravic J; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UK.
  • Kim YJ; Department of Biostatistics, University of Liverpool, Liverpool, UK.
  • Rybin DV; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
  • Yaghootkar H; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Müller-Nurasyid M; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Meidtner K; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Li-Gao R; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Varga TV; Department of Clinical Sciences, Diabetes, and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
  • Marten J; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea.
  • Li J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Smith AV; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
  • An P; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Ligthart S; Department of Medicine I, University Hospital Großhadern, Ludwig-Maximilians-Universität, Munich, Germany.
  • Gustafsson S; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • Malerba G; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
  • Demirkan A; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Tajes JF; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Steinthorsdottir V; Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
  • Wuttke M; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Lecoeur C; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Preuss M; Icelandic Heart Association, Kopavogur, Iceland.
  • Bielak LF; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  • Graff M; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.
  • Highland HM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Justice AE; Department of Medical Sciences, Molecular Epidemiology, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Liu DJ; Section of Biology and Genetics, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy.
  • Marouli E; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Nat Genet ; 50(4): 559-571, 2018 04.
Article em En | MEDLINE | ID: mdl-29632382
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Diagnostic_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Diagnostic_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article