Ursodeoxycholate Restores Biliary Excretion of Methotrexate in Rats with Ethinyl Estradiol Induced-Cholestasis by Restoring Canalicular Mrp2 Expression.

Kim, Min Ju; Kang, Yun Ju; Kwon, Mihwa; Choi, Young A; Choi, Min-Koo; Chi, Hye-Young; Yoo, Hye Hyun; Shim, Chang-Koo; Song, Im-Sook

Kim, Min Ju; Kang, Yun Ju; Kwon, Mihwa; Choi, Young A; Choi, Min-Koo; Chi, Hye-Young; Yoo, Hye Hyun; Shim, Chang-Koo; Song, Im-Sook.

Afiliação

Kim MJ; Life Science Institute, Daewoong Pharmaceutical, Yongin, Gyeonggi-do 17028, Korea. yunijjan83@gmail.com.
Kang YJ; College of Pharmacy, Hanyang University, An-san, Gyeonggi-do 15588, Korea. yunijjan83@gmail.com.
Kwon M; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea. yun-ju6895@nate.com.
Choi YA; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea. mihwa_k@naver.com.
Choi MK; College of Pharmacy, Dankook University, Cheon-an 31116, Korea. ayha06@gmail.com.
Chi HY; College of Pharmacy, Dankook University, Cheon-an 31116, Korea. minkoochoi@dankook.ac.kr.
Yoo HH; Life Science Institute, Daewoong Pharmaceutical, Yongin, Gyeonggi-do 17028, Korea. hychi138@daewoong.co.kr.
Shim CK; College of Pharmacy, Hanyang University, An-san, Gyeonggi-do 15588, Korea. yoohh@hanyang.ac.kr.
Song IS; Life Science Institute, Daewoong Pharmaceutical, Yongin, Gyeonggi-do 17028, Korea. shimck@daewoong.co.kr.

Int J Mol Sci ; 19(4)2018 Apr 09.

Article em En | MEDLINE | ID: mdl-29642532

Assuntos

Ácidos e Sais Biliares/química; Colestase/prevenção & controle; Etinilestradiol/efeitos adversos; Metotrexato/sangue; Ácido Ursodesoxicólico/administração & dosagem; Transportadores de Cassetes de Ligação de ATP/metabolismo; Administração Oral; Animais; Colestase/sangue; Colestase/induzido quimicamente; Colestase/metabolismo; Regulação para Baixo; Esquema de Medicação; Masculino; Proteína 2 Associada à Farmacorresistência Múltipla; Ratos; Resultado do Tratamento; Ácido Ursodesoxicólico/farmacologia

Palavras-chave

biliary excretion clearance; intrahepatic cholestasis; methotrexate (MTX); multidrug resistance-associated protein (Mrp) 2; ursodeoxycholate (UDCA)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Ursodesoxicólico / Ácidos e Sais Biliares / Metotrexato / Colestase / Etinilestradiol Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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