A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process.
Br J Dermatol
; 179(3): 642-650, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-29654696
ABSTRACT
BACKGROUND:
There is no consensus on core outcome domains for hidradenitis suppurativa (HS). Heterogeneous outcome measure instruments in clinical trials likely leads to outcome-reporting bias and limits the ability to synthesize evidence.OBJECTIVES:
To achieve global multistakeholder consensus on a core outcome set (COS) of domains regarding what to measure in clinical trials for HS.METHODS:
Six stakeholder groups participated in a Delphi process that included five anonymous e-Delphi rounds and four face-to-face consensus meetings to reach consensus on the final COS. The aim was for a 1 1 ratio of patients to healthcare professionals (HCPs).RESULTS:
A total of 41 patients and 52 HCPs from 19 countries in four continents participated in the consensus process, which yielded a final COS that included five domains pain, physical signs, HS-specific quality of life, global assessment and progression of course. A sixth domain, symptoms, was highly supported by patients and not by HCPs but is recommended for the core domain set.CONCLUSIONS:
Routine adoption of the COS in future HS trials should ensure that core outcomes of importance to both patients and HCPs are collected.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ensaios Clínicos como Assunto
/
Técnica Delphi
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Hidradenite Supurativa
/
Medidas de Resultados Relatados pelo Paciente
Tipo de estudo:
Guideline
/
Qualitative_research
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article