Cortical spreading depression as a site of origin for migraine: Role of CGRP.
Cephalalgia
; 39(3): 428-434, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-29695168
ABSTRACT
PREMISE Migraine is a complex neurologic disorder that leads to significant disability, yet remains poorly understood. PROBLEM:
One potential triggering mechanism in migraine with aura is cortical spreading depression, which can activate the trigeminal nociceptive system both peripherally and centrally in animal models. A primary neuropeptide of the trigeminal system is calcitonin gene-related peptide, which is a potent vasodilatory peptide and is currently a major therapeutic target for migraine treatment. Despite the importance of both cortical spreading depression and calcitonin gene-related peptide in migraine, the relationship between these two players has been relatively unexplored. However, recent data suggest several potential vascular and neural connections between calcitonin gene-related peptide and cortical spreading depression.CONCLUSION:
This review will outline calcitonin gene-related peptide-cortical spreading depression connections and propose a model in which cortical spreading depression and calcitonin gene-related peptide act at the intersection of the vasculature and cortical neurons, and thus contribute to migraine pathophysiology.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Depressão Alastrante da Atividade Elétrica Cortical
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Vasodilatação
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Peptídeo Relacionado com Gene de Calcitonina
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Transtornos de Enxaqueca
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article