Metal- and Base-Free Room-Temperature Amination of Organoboronic Acids with N-Alkyl Hydroxylamines.
Angew Chem Int Ed Engl
; 57(30): 9456-9460, 2018 07 20.
Article
em En
| MEDLINE
| ID: mdl-29736974
ABSTRACT
We have found that readily available N-alkyl hydroxylamines are effective reagents for the amination of organoboronic acids in the presence of trichloroacetonitrile. This amination reaction proceeds rapidly at room temperature and in the absence of added metal or base, it tolerates a remarkable range of functional groups, and it can be used in the late-stage assembly of two complex units.
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MEDLINE
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En
Ano de publicação:
2018
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Article