Methylphenidate-mediated motor control network enhancement in patients with traumatic brain injury.
Brain Inj
; 32(8): 1040-1049, 2018.
Article
em En
| MEDLINE
| ID: mdl-29738277
ABSTRACT
PRIMARY OBJECTIVE:
To investigate functional improvement late (>6 months) after traumatic brain injury (TBI). To this end, we conducted a double-blind, placebo-controlled experimental medicine study to test the hypothesis that a widely used cognitive enhancer would benefit patients with TBI. RESEARCHDESIGN:
We focused on motor control function using a sequential finger opposition fMRI paradigm in both patients and age-matched controls. METHODS AND PROCEDURES Patients' fMRI and DTI scans were obtained after randomised administration of methylphenidate or placebo. Controls were scanned without intervention. To assess differences in motor speed, we compared reaction times from the baseline condition of a sustained attention task. MAIN OUTCOMES ANDRESULTS:
Patients' reaction times correlated with wide-spread motor-related white matter abnormalities. Administration of methylphenidate resulted in faster reaction times in patients, which were not significantly different from those achieved by controls. This was also reflected in the fMRI findings in that patients on methylphenidate activated the left inferior frontal gyrus significantly more than when on placebo. Furthermore, stronger functional connections between pre-/post-central cortices and cerebellum were noted for patients on methylphenidate.CONCLUSIONS:
Our findings suggest that residual functionality in patients with TBI may be enhanced by a single dose of methylphenidate.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lesões Encefálicas Traumáticas
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Estimulantes do Sistema Nervoso Central
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Metilfenidato
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Atividade Motora
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Vias Neurais
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article