Thermotherapy for Harding-Passey melanoma: light and electron microscopic study.

The changes of implanted Harding-Passey melanoma in C57Bl/6J mice following treatment with wholebody hyperthermia were studied. The treated tumours showed a progressive growth delay, cellular and architectural irregularities as well as cell injury characteristics. The presence of distended and irregular blood vessels, the peripheral localization of the melanosomes and the melanosome complexes were constant.