Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro.
J Clin Invest
; 75(1): 306-9, 1985 Jan.
Article
em En
| MEDLINE
| ID: mdl-2981251
ABSTRACT
Human small cell lung carcinoma (SCLC) cells have been shown to contain significant levels of a bombesin-immunoreactive peptide. The 27-amino acid peptide, gastrin releasing peptide (GRP), has recently been shown to be responsible for the bombesin-like immunoreactivity found in SCLC cells. Among four lung cancer cell lines examined in vitro, GRP exhibited mitogenic activity for two SCLC subtypes, but not for a squamous carcinoma or adenocarcinoma lung cell line. The mitogenicity of the GRP molecule has been isolated to the carboxyterminal fragment, designated GRP 14-27, which is in part homologous to bombesin. The aminoterminal fragment, GRP 1-16, is no homologous to bombesin and exhibits no mitogenic activity. Thus, GRP may be an important growth regulating or autocrine factor in human SCLC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Carcinoma de Células Pequenas
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Neoplasias Pulmonares
/
Mitógenos
Limite:
Humans
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article