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Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography.
Olmos, Jose L; Pandey, Suraj; Martin-Garcia, Jose M; Calvey, George; Katz, Andrea; Knoska, Juraj; Kupitz, Christopher; Hunter, Mark S; Liang, Mengning; Oberthuer, Dominik; Yefanov, Oleksandr; Wiedorn, Max; Heyman, Michael; Holl, Mark; Pande, Kanupriya; Barty, Anton; Miller, Mitchell D; Stern, Stephan; Roy-Chowdhury, Shatabdi; Coe, Jesse; Nagaratnam, Nirupa; Zook, James; Verburgt, Jacob; Norwood, Tyler; Poudyal, Ishwor; Xu, David; Koglin, Jason; Seaberg, Matthew H; Zhao, Yun; Bajt, Sasa; Grant, Thomas; Mariani, Valerio; Nelson, Garrett; Subramanian, Ganesh; Bae, Euiyoung; Fromme, Raimund; Fung, Russell; Schwander, Peter; Frank, Matthias; White, Thomas A; Weierstall, Uwe; Zatsepin, Nadia; Spence, John; Fromme, Petra; Chapman, Henry N; Pollack, Lois; Tremblay, Lee; Ourmazd, Abbas; Phillips, George N; Schmidt, Marius.
Afiliação
  • Olmos JL; Department of BioSciences, Rice University, 6100 Main Street, Houston, TX, 77005, USA.
  • Pandey S; Physics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA.
  • Martin-Garcia JM; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA.
  • Calvey G; School of Applied and Engineering Physics, Cornell University, 254 Clark Hall, Ithaca, NY, 14853, USA.
  • Katz A; School of Applied and Engineering Physics, Cornell University, 254 Clark Hall, Ithaca, NY, 14853, USA.
  • Knoska J; Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607, Hamburg, Germany.
  • Kupitz C; University of Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
  • Hunter MS; Physics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA.
  • Liang M; Linac Coherent Light Source, Stanford Linear Accelerator Center (SLAC) National, Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA, 94025, USA.
  • Oberthuer D; Linac Coherent Light Source, Stanford Linear Accelerator Center (SLAC) National, Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA, 94025, USA.
  • Yefanov O; Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607, Hamburg, Germany.
  • Wiedorn M; Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607, Hamburg, Germany.
  • Heyman M; Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607, Hamburg, Germany.
  • Holl M; University of Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
  • Pande K; Max Planck Institut fuer Biochemie, Am Klopferspitz 18, 82152, Planegg, Germany.
  • Barty A; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA.
  • Miller MD; Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA, 94720, USA.
  • Stern S; Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607, Hamburg, Germany.
  • Roy-Chowdhury S; Department of BioSciences, Rice University, 6100 Main Street, Houston, TX, 77005, USA.
  • Coe J; Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607, Hamburg, Germany.
  • Nagaratnam N; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA.
  • Zook J; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA.
  • Verburgt J; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA.
  • Norwood T; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA.
  • Poudyal I; Physics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA.
  • Xu D; Milwaukee School of Engineering, Milwaukee, WI, 53202-3109, USA.
  • Koglin J; Physics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA.
  • Seaberg MH; Physics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA.
  • Zhao Y; Department of BioSciences, Rice University, 6100 Main Street, Houston, TX, 77005, USA.
  • Bajt S; Linac Coherent Light Source, Stanford Linear Accelerator Center (SLAC) National, Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA, 94025, USA.
  • Grant T; Linac Coherent Light Source, Stanford Linear Accelerator Center (SLAC) National, Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA, 94025, USA.
  • Mariani V; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA.
  • Nelson G; Photon Science, DESY, Notkestrasse 85, 22607, Hamburg, Germany.
  • Subramanian G; University of New York Buffalo, Hauptman-Woodward Institute, 700 Ellicott St, Buffalo, NY, 14203, USA.
  • Bae E; Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607, Hamburg, Germany.
  • Fromme R; Department of Physics, Arizona State University, Tempe, AZ, 85287, USA.
  • Fung R; Department of Physics, Arizona State University, Tempe, AZ, 85287, USA.
  • Schwander P; Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Korea.
  • Frank M; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA.
  • White TA; Physics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA.
  • Weierstall U; Physics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA.
  • Zatsepin N; Lawrence Livermore National Laboratory, Livermore, CA, 94550, USA.
  • Spence J; Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607, Hamburg, Germany.
  • Fromme P; Department of Physics, Arizona State University, Tempe, AZ, 85287, USA.
  • Chapman HN; Department of Physics, Arizona State University, Tempe, AZ, 85287, USA.
  • Pollack L; Department of Physics, Arizona State University, Tempe, AZ, 85287, USA.
  • Tremblay L; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA.
  • Ourmazd A; Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607, Hamburg, Germany.
  • Phillips GN; University of Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
  • Schmidt M; Centre for Ultrafast Imaging, Luruper Chaussee 149, 22761, Hamburg, Germany.
BMC Biol ; 16(1): 59, 2018 05 31.
Article em En | MEDLINE | ID: mdl-29848358

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Ceftriaxona / Cristalografia por Raios X / Antibacterianos / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Ceftriaxona / Cristalografia por Raios X / Antibacterianos / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article