Automated GMP-production of α-[11 C]methyl-L-tryptophan using a tracer production system (TPS).
J Labelled Comp Radiopharm
; 61(14): 1106-1109, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-29902836
ABSTRACT
The radiosynthesis and GMP validation of [11 C]AMT for human use are described. Three consecutive batches were produced giving 940-3790 MBq (4%-17% RCY, decay corrected, based on [11 C]CO2 ) of the tracer. The molar activity at the end of synthesis was 19 to 35 GBq/µmol, the radiochemical purity was ≥98%, and the enantiomeric purity was >99%. While the synthesis method was automated using a new generation of synthesis equipment, tracer production system developed in house, the method should be readily applicable to other synthesis platforms with minor modifications.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Radioquímica
/
Triptofano
/
Radioisótopos de Carbono
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article