Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.
Cell Metab
; 28(2): 282-288.e3, 2018 08 07.
Article
em En
| MEDLINE
| ID: mdl-29909970
ABSTRACT
Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα+ preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting.
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Base de dados:
MEDLINE
Assunto principal:
Lactação
/
Tecido Adiposo
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Adipogenia
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Adipócitos Brancos
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Glândulas Mamárias Animais
Limite:
Animals
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Pregnancy
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article