Glutathione peroxidase, glutathione S-transferase and glutathione reductase activities in normal and neoplastic human breast tissue.
Cancer Lett
; 29(1): 37-42, 1985 Oct.
Article
em En
| MEDLINE
| ID: mdl-2998588
ABSTRACT
Glutathione peroxidase (GSH-Px), glutathione S-transferase (GSH-Tr) and glutathione reductase (GSSG-Rx) activities have been determined in normal and neoplastic human breast tissues. Large interindividual variations in the activities of all enzymes tested were found in both tumor and non-tumor specimens. In general a significant increase in the activities of the 3 enzymes was found in tumors, whereas in fibroadenoma they were as high as in healthy tissues. When a comparison was made between normal and neoplastic tissues of the same individual, GSH-Tr and GSSG-Rx activities were found to be higher in 15 and 11 cases, respectively, out of 17. GSG-Px activity was higher in all cases. From measurement of GSG-Px activity with both H202 and cumene hydroperoxide, it was deduced that human breast contains only the selenium-dependent form.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Adenofibroma
/
Carcinoma Intraductal não Infiltrante
/
Glutationa Peroxidase
/
Glutationa Redutase
/
Glutationa Transferase
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article