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Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study.
He, Yazhou; Timofeeva, Maria; Farrington, Susan M; Vaughan-Shaw, Peter; Svinti, Victoria; Walker, Marion; Zgaga, Lina; Meng, Xiangrui; Li, Xue; Spiliopoulou, Athina; Jiang, Xia; Hyppönen, Elina; Kraft, Peter; Kiel, Douglas P; Hayward, Caroline; Campbell, Archie; Porteous, David; Vucic, Katarina; Kirac, Iva; Filipovic, Masa; Harris, Sarah E; Deary, Ian J; Houlston, Richard; Tomlinson, Ian P; Campbell, Harry; Theodoratou, Evropi; Dunlop, Malcolm G.
Afiliação
  • He Y; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Timofeeva M; West China School of Medicine/West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
  • Farrington SM; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, EH8 9AG, UK.
  • Vaughan-Shaw P; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Svinti V; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Walker M; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Zgaga L; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Meng X; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Li X; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Spiliopoulou A; Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, University of Dublin, Dublin 24, D02 PN40, Ireland.
  • Jiang X; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, EH8 9AG, UK.
  • Hyppönen E; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, EH8 9AG, UK.
  • Kraft P; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, EH8 9AG, UK.
  • Kiel DP; Program in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.
  • Hayward C; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, University of South Australia, Adelaide, SA, 5001, Australia.
  • Campbell A; Population, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health, WC1E 6BT, London, UK.
  • Porteous D; Program in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.
  • Vucic K; Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA.
  • Kirac I; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02115, USA.
  • Filipovic M; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA, 02142, USA.
  • Deary IJ; MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
  • Houlston R; Generation Scotland, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
  • Tomlinson IP; Generation Scotland, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
  • Campbell H; Agency for Medicinal Products and Medical Devices, Department for Quality, Safety and Efficacy Assessment, Zagreb, Croatia.
  • Theodoratou E; Department of Surgical Oncology, University Hospital for Tumours, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.
  • Dunlop MG; School of Medicine, University of Zagreb, Zagreb, Croatia.
BMC Med ; 16(1): 142, 2018 08 14.
Article em En | MEDLINE | ID: mdl-30103784
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vitamina D / Neoplasias Colorretais / Análise da Randomização Mendeliana Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vitamina D / Neoplasias Colorretais / Análise da Randomização Mendeliana Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article