Does the MHC Confer Protection against Malaria in Bonobos?

de Groot, Natasja G; Stevens, Jeroen M G; Bontrop, Ronald E

de Groot, Natasja G; Stevens, Jeroen M G; Bontrop, Ronald E.

Afiliação

de Groot NG; Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Rijswijk, The Netherlands.
Stevens JMG; Centre for Research and Conservation, Royal Zoological Society of Antwerp, Antwerp, Belgium; Department of Biology, University of Antwerp, Antwerp, Belgium.
Bontrop RE; Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Rijswijk, The Netherlands; Department of Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands. Electronic address: bontrop@bprc.nl.

Trends Immunol ; 39(10): 768-771, 2018 10.

Article em En | MEDLINE | ID: mdl-30126696

RESUMO

The immunological factors that could explain the near absence of malaria parasites in bonobos are not yet understood. The MHC class I system, however, may play an important role, as particular bonobo allotypes show functional similarities to HLA-B*53/B*78, which are considered to confer protection against malaria in humans.

Assuntos

Genótipo; Antígenos HLA/genética; Antígenos HLA-B/genética; Antígenos de Histocompatibilidade Classe I/genética; Malária/genética; Pan paniscus/imunologia; Alelos; Animais; Predisposição Genética para Doença; Humanos; Malária/imunologia; Polimorfismo Genético; Alinhamento de Sequência

Palavras-chave

HIV; HLA; MHC; bonobo; chimpanzee; malaria

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Classe I / Antígenos HLA-B / Pan paniscus / Genótipo / Antígenos HLA / Malária Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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