m<sup>6</sup>A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.

Liu, Jun; Eckert, Mark A; Harada, Bryan T; Liu, Song-Mei; Lu, Zhike; Yu, Kangkang; Tienda, Samantha M; Chryplewicz, Agnieszka; Zhu, Allen C; Yang, Ying; Huang, Jing-Tao; Chen, Shao-Min; Xu, Zhi-Gao; Leng, Xiao-Hua; Yu, Xue-Chen; Cao, Jie; Zhang, Zezhou; Liu, Jianzhao; Lengyel, Ernst; He, Chuan

m⁶A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.

Liu, Jun; Eckert, Mark A; Harada, Bryan T; Liu, Song-Mei; Lu, Zhike; Yu, Kangkang; Tienda, Samantha M; Chryplewicz, Agnieszka; Zhu, Allen C; Yang, Ying; Huang, Jing-Tao; Chen, Shao-Min; Xu, Zhi-Gao; Leng, Xiao-Hua; Yu, Xue-Chen; Cao, Jie; Zhang, Zezhou; Liu, Jianzhao; Lengyel, Ernst; He, Chuan.

Afiliação

Liu J; Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.
Eckert MA; Howard Hughes Medical Institute, Chicago, IL, USA.
Harada BT; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, IL, USA.
Liu SM; Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.
Lu Z; Howard Hughes Medical Institute, Chicago, IL, USA.
Yu K; Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China.
Tienda SM; Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.
Chryplewicz A; Howard Hughes Medical Institute, Chicago, IL, USA.
Zhu AC; Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.
Yang Y; Howard Hughes Medical Institute, Chicago, IL, USA.
Huang JT; College of Chemistry, Sichuan University, Chengdu, China.
Chen SM; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, IL, USA.
Xu ZG; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, IL, USA.
Leng XH; Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.
Yu XC; Howard Hughes Medical Institute, Chicago, IL, USA.
Cao J; Committee on Cancer Biology and Medical Scientist Training Program, The University of Chicago, Chicago, IL, USA.
Zhang Z; Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China.
Liu J; Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China.
Lengyel E; Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China.
He C; Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Nat Cell Biol ; 20(9): 1074-1083, 2018 09.

Article em En | MEDLINE | ID: mdl-30154548

Assuntos

Adenosina/análogos & derivados; Carcinogênese; Proliferação de Células; Neoplasias do Endométrio/enzimologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Processamento Pós-Transcricional do RNA; RNA Mensageiro/metabolismo; RNA Neoplásico/metabolismo; Adenosina/genética; Adenosina/metabolismo; Animais; Linhagem Celular Tumoral; Neoplasias do Endométrio/genética; Neoplasias do Endométrio/patologia; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Alvo Mecanístico do Complexo 2 de Rapamicina/genética; Alvo Mecanístico do Complexo 2 de Rapamicina/metabolismo; Metilação; Metiltransferases/genética; Metiltransferases/metabolismo; Camundongos Nus; Mutação; Fosfoproteínas Fosfatases/genética; Fosfoproteínas Fosfatases/metabolismo; RNA Mensageiro/genética; RNA Neoplásico/genética; Transdução de Sinais; Fatores de Tempo; Carga Tumoral

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Mensageiro / RNA Neoplásico / Adenosina / Processamento Pós-Transcricional do RNA / Neoplasias do Endométrio / Proliferação de Células / Proteínas Proto-Oncogênicas c-akt / Carcinogênese Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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