Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses.
Proc Natl Acad Sci U S A
; 115(45): 11579-11584, 2018 11 06.
Article
em En
| MEDLINE
| ID: mdl-30249666
ABSTRACT
Adaptive natural killer (NK) cell memory represents a new frontier in immunology. Work over the last decade has discovered and confirmed the existence of NK cells with antigen-specific memories, which had previously been considered a unique property of T and B cells. These findings have shown that antigen-specific NK cells gain their specificity without the use of RAG proteins, representing a novel mechanism for generating antigen specificity, but the details of this mechanism have remained a mystery. We have discovered that members of the Ly49 family of surface receptors are critically involved in both the sensitization and the challenge phases of an NK cell memory response, as is antigen presentation from their binding partner, the class I MHC. Moreover, we demonstrate that the Ly49-interacting component of a presented antigen dictates the specificity of the NK cell memory response, implicating Ly49 receptors themselves in antigen-specific recognition. Finally, we demonstrate that adaptive NK cell memories can protect against an otherwise lethal melanoma without T cell or B cell support. These findings offer insight into the mechanism behind NK cell antigen specificity and demonstrate the clinical potential of this adaptive immune cell.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Melanoma Experimental
/
Células Matadoras Naturais
/
Dermatite de Contato
/
Subfamília A de Receptores Semelhantes a Lectina de Células NK
/
Memória Imunológica
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article