HMGB1: LPS Delivery Vehicle for Caspase-11-Mediated Pyroptosis.

Kim, Ho Min; Kim, You-Me

Kim, Ho Min; Kim, You-Me.

Afiliação

Kim HM; Graduate School of Medical Science & Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea. Electronic address: hm_kim@kaist.ac.kr.
Kim YM; Graduate School of Medical Science & Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea. Electronic address: youmekim@kaist.ac.kr.

Immunity ; 49(4): 582-584, 2018 10 16.

Article em En | MEDLINE | ID: mdl-30332623

ABSTRACT

ABSTRACT

Recognition of cytoplasmic lipopolysaccharide (LPS) by caspase-11 leads to pyroptosis and secretion of inflammatory mediators. In this issue of Immunity, Deng et al. (2018) report that high-mobility group box 1 (HMGB1) secreted by hepatocytes delivers extracellular LPS into the cytoplasm and mediates pyroptosis.

Assuntos

Proteína HMGB1; Sepse; Caspases; Endotoxinas; Humanos; Lipopolissacarídeos; Piroptose

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Proteína HMGB1 Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Proteína HMGB1 Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article