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NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2.
Zhou, Xue-Liang; Zhu, Rong-Rong; Wu, Xia; Xu, Hua; Li, Yun-Yun; Xu, Qi-Rong; Liu, Sheng; Huang, Huang; Xu, Xinping; Wan, Li; Wu, Qi-Cai; Liu, Ji-Chun.
Afiliação
  • Zhou XL; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Zhu RR; Department of Obstetrics and Gynecology, Jiangxi Province Hospital of Integrated Traditional Chinese and Western Medicine, Nanchang, China.
  • Wu X; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Xu H; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Li YY; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Xu QR; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Liu S; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Huang H; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Xu X; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Wan L; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Wu QC; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Liu JC; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
J Cell Mol Med ; 23(1): 568-575, 2019 01.
Article em En | MEDLINE | ID: mdl-30334333
ABSTRACT
Histone lysine methylation plays an important role in the regulation of ventricular remodelling. NSD2 is involved in many types of tumours through enhancing H3K36me2 expression. However, the role of NSD2 in the regulation of histone lysine methylation during ventricular remodelling remains unclear. In this study, we established cardiac hypertrophy model in C57BL/6 mice by transverse aortic constriction and found that histone lysine methylation participated in ventricular remodelling regulation via the up-regulation of H3K27me2 and H3K36me2 expression. In addition, we constructed transgenic C57BL/6 mice with conditional knockout of NSD2 (NSD2-/- ) in the myocardium. NSD2-/- C57BL/6 mice had milder ventricular remodelling and significantly improved cardiac function compared with wild-type mice, and the expression of H3K36me2 but not H3K27me2 was down-regulated. In conclusion, NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histonas / Histona-Lisina N-Metiltransferase / Remodelação Ventricular Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histonas / Histona-Lisina N-Metiltransferase / Remodelação Ventricular Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article