Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity.
Eur J Med Chem
; 160: 146-156, 2018 Dec 05.
Article
em En
| MEDLINE
| ID: mdl-30336449
ABSTRACT
The development of novel photosensitizers is a challenging task for photodynamic therapy (PDT). Twelve novel photosensitizers (PSs), including porphins (P1-4), chlorins (C1-4) and bacteriochlorins (B1-4) were synthesized. The bacteriochlorins exhibited the longest absorption wavelength (λmaxâ¯=â¯736â¯nm), which is higher than that of porphins (λmaxâ¯=â¯630â¯nm) and chlorins (λmaxâ¯=â¯644â¯nm). In vitro photodynamic activities on Eca-109 human esophageal carcinoma cells were evaluated by standard assays and all PSs showed photodynamic activity. Among them, B2 displayed the highest phototoxicity and the lowest dark toxicity. In addition, B2 exhibited best photodynamic antitumor efficacy on BALB/c nude mice bearing Eca-109â¯cells tumor. Therefore, B2 is a powerful and promising antitumor photosensitizer for PDT.
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Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
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Porfirinas
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Neoplasias Esofágicas
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Fármacos Fotossensibilizantes
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article