Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects.

Kwon, Min Jee; Han, Myeong Hoon; Bagley, Joshua A; Hyeon, Do Young; Ko, Byung Su; Lee, Yun Mi; Cha, In Jun; Kim, Seung Yeol; Kim, Dong Young; Kim, Ho Min; Hwang, Daehee; Lee, Sung Bae; Jan, Yuh Nung

Kwon, Min Jee; Han, Myeong Hoon; Bagley, Joshua A; Hyeon, Do Young; Ko, Byung Su; Lee, Yun Mi; Cha, In Jun; Kim, Seung Yeol; Kim, Dong Young; Kim, Ho Min; Hwang, Daehee; Lee, Sung Bae; Jan, Yuh Nung.

Afiliação

Kwon MJ; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, 42988 Daegu, Republic of Korea.
Han MH; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, 42988 Daegu, Republic of Korea.
Bagley JA; Department of Physiology, University of California, San Francisco, CA 94158.
Hyeon DY; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.
Ko BS; Howard Hughes Medical Institute, University of California, San Francisco, CA 94158.
Lee YM; Center for Plant Aging Research, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology, 42988 Daegu, Republic of Korea.
Cha IJ; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, 42988 Daegu, Republic of Korea.
Kim SY; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, 42988 Daegu, Republic of Korea.
Kim DY; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, 42988 Daegu, Republic of Korea.
Kim HM; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, 42988 Daegu, Republic of Korea.
Hwang D; College of Pharmacy, Yeungnam University, Gyeongsan, 38541 Gyeongbuk, Republic of Korea.
Lee SB; Graduate School of Medical Science & Engineering, Korea Advanced Institute of Science and Technology, 34141 Daejeon, Republic of Korea.
Jan YN; Center for Plant Aging Research, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology, 42988 Daegu, Republic of Korea; dhwang@dgist.ac.kr sblee@dgist.ac.kr Yuhnung.jan@ucsf.edu.

Proc Natl Acad Sci U S A ; 115(45): E10748-E10757, 2018 11 06.

Article em En | MEDLINE | ID: mdl-30348793

Assuntos

Ataxina-3/química; Proteínas de Drosophila/química; Drosophila melanogaster/genética; Fatores de Transcrição Forkhead/química; Neurônios/metabolismo; Peptídeos/química; Ataxias Espinocerebelares/genética; Sequência de Aminoácidos; Animais; Ataxina-3/genética; Ataxina-3/metabolismo; Comportamento Animal; Sítios de Ligação; Núcleo Celular/metabolismo; Modelos Animais de Doenças; Proteínas de Drosophila/genética; Proteínas de Drosophila/metabolismo; Drosophila melanogaster/metabolismo; Fatores de Transcrição Forkhead/genética; Fatores de Transcrição Forkhead/metabolismo; Humanos; Mutação; Neurônios/ultraestrutura; Peptídeos/genética; Peptídeos/metabolismo; Ligação Proteica; Conformação Proteica em alfa-Hélice; Conformação Proteica em Folha beta; Domínios e Motivos de Interação entre Proteínas; Ataxias Espinocerebelares/metabolismo; Ataxias Espinocerebelares/patologia

Palavras-chave

Foxo; coiled coil; dendrites; neurodegenerative diseases; polyQ

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Ataxias Espinocerebelares / Proteínas de Drosophila / Drosophila melanogaster / Fatores de Transcrição Forkhead / Ataxina-3 / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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