Nanoparticle-Mediated Targeting of Pitavastatin to Small Pulmonary Arteries and Leukocytes by Intravenous Administration Attenuates the Progression of Monocrotaline-Induced Established Pulmonary Arterial Hypertension in Rats.

Ichimura, Kenzo; Matoba, Tetsuya; Koga, Jun-Ichiro; Nakano, Kaku; Funamoto, Daiki; Tsutsui, Hiroyuki; Egashira, Kensuke

Ichimura, Kenzo; Matoba, Tetsuya; Koga, Jun-Ichiro; Nakano, Kaku; Funamoto, Daiki; Tsutsui, Hiroyuki; Egashira, Kensuke.

Afiliação

Ichimura K; Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences.
Matoba T; Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences.
Koga JI; Department of Cardiovascular Research, Development, and Translational Medicine, Center for Disruptive Cardiovascular Medicine, Kyushu University.
Nakano K; Department of Cardiovascular Research, Development, and Translational Medicine, Center for Disruptive Cardiovascular Medicine, Kyushu University.
Funamoto D; Department of Cardiovascular Research, Development, and Translational Medicine, Center for Disruptive Cardiovascular Medicine, Kyushu University.
Tsutsui H; Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences.
Egashira K; Department of Cardiovascular Research, Development, and Translational Medicine, Center for Disruptive Cardiovascular Medicine, Kyushu University.

Int Heart J ; 59(6): 1432-1444, 2018 Nov 28.

Article em En | MEDLINE | ID: mdl-30369578

Assuntos

Sistemas de Liberação de Medicamentos/métodos; Inibidores de Hidroximetilglutaril-CoA Redutases/administração & dosagem; Hipertensão Pulmonar/tratamento farmacológico; Nanopartículas/administração & dosagem; Quinolinas/administração & dosagem; Administração Intravenosa; Animais; Progressão da Doença; Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico; Hipertensão Pulmonar/induzido quimicamente; Leucócitos; Masculino; Monocrotalina; Artéria Pulmonar; Quinolinas/uso terapêutico; Distribuição Aleatória; Ratos; Ratos Sprague-Dawley; Resultado do Tratamento

Palavras-chave

Pulmonary hypertension; Statin; Translational study

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Sistemas de Liberação de Medicamentos / Inibidores de Hidroximetilglutaril-CoA Redutases / Nanopartículas / Hipertensão Pulmonar Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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