Cryo-EM structure of the NLRC4<sup>CARD</sup> filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly.

Matyszewski, Mariusz; Zheng, Weili; Lueck, Jacob; Antiochos, Brendan; Egelman, Edward H; Sohn, Jungsan

Cryo-EM structure of the NLRC4^CARD filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly.

Matyszewski, Mariusz; Zheng, Weili; Lueck, Jacob; Antiochos, Brendan; Egelman, Edward H; Sohn, Jungsan.

Afiliação

Matyszewski M; From the Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Zheng W; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, and.
Lueck J; From the Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Antiochos B; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Egelman EH; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, and. Electronic address: egelman@virginia.edu.
Sohn J; From the Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205,. Electronic address: jsohn@jhmi.edu.

J Biol Chem ; 293(52): 20240-20248, 2018 12 28.

Article em En | MEDLINE | ID: mdl-30385506

Assuntos

Proteínas Adaptadoras de Sinalização CARD/química; Proteínas de Ligação ao Cálcio/química; Modelos Moleculares; Complexos Multiproteicos/química; Proteína Inibidora de Apoptose Neuronal/química; Proteínas Adaptadoras de Sinalização CARD/metabolismo; Proteínas de Ligação ao Cálcio/metabolismo; Microscopia Crioeletrônica; Humanos; Complexos Multiproteicos/metabolismo; Complexos Multiproteicos/ultraestrutura; Proteína Inibidora de Apoptose Neuronal/metabolismo; Estrutura Quaternária de Proteína

Palavras-chave

Monte Carlo simulation; NLRC4; biophysics; caspase; cryo-electron microscopy; inflammasome; innate immunity; nod-like receptor (NLR); pyroptosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Modelos Moleculares / Complexos Multiproteicos / Proteína Inibidora de Apoptose Neuronal / Proteínas Adaptadoras de Sinalização CARD Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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