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Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis.
Rees, Elliott; Carrera, Noa; Morgan, Joanne; Hambridge, Kirsty; Escott-Price, Valentina; Pocklington, Andrew J; Richards, Alexander L; Pardiñas, Antonio F; McDonald, Colm; Donohoe, Gary; Morris, Derek W; Kenny, Elaine; Kelleher, Eric; Gill, Michael; Corvin, Aiden; Kirov, George; Walters, James T R; Holmans, Peter; Owen, Michael J; O'Donovan, Michael C.
Afiliação
  • Rees E; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Carrera N; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Morgan J; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Hambridge K; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Escott-Price V; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Pocklington AJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Richards AL; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Pardiñas AF; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • McDonald C; Centre for Neuroimaging and Cognitive Genomics, National University of Ireland Galway, Galway, Ireland.
  • Donohoe G; Centre for Neuroimaging and Cognitive Genomics, National University of Ireland Galway, Galway, Ireland.
  • Morris DW; Centre for Neuroimaging and Cognitive Genomics, National University of Ireland Galway, Galway, Ireland.
  • Kenny E; Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Kelleher E; Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Gill M; Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Corvin A; Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Kirov G; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Walters JTR; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Holmans P; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom. Electronic address: owenmj@cardiff.ac.uk.
  • O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom. Electronic address: odonovanmc@cardiff.ac.uk.
Biol Psychiatry ; 85(7): 554-562, 2019 04 01.
Article em En | MEDLINE | ID: mdl-30420267
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Análise de Sequência de DNA / Receptores de N-Metil-D-Aspartato / Proteínas do Citoesqueleto / Canais de Sódio Disparados por Voltagem / Proteínas do Tecido Nervoso / Neurônios Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Humans / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Análise de Sequência de DNA / Receptores de N-Metil-D-Aspartato / Proteínas do Citoesqueleto / Canais de Sódio Disparados por Voltagem / Proteínas do Tecido Nervoso / Neurônios Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Humans / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article