Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer.

Chen, Miaomiao; Zhang, Hongqin; Zhang, Guihong; Zhong, Ailing; Ma, Qian; Kai, Jinyan; Tong, Yin; Xie, Suhong; Wang, Yanchun; Zheng, Hui; Guo, Lin; Lu, Renquan

Chen, Miaomiao; Zhang, Hongqin; Zhang, Guihong; Zhong, Ailing; Ma, Qian; Kai, Jinyan; Tong, Yin; Xie, Suhong; Wang, Yanchun; Zheng, Hui; Guo, Lin; Lu, Renquan.

Afiliação

Chen M; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Zhang H; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Zhang G; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Zhong A; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Ma Q; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Kai J; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Tong Y; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.
Xie S; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.
Wang Y; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.
Zheng H; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.
Guo L; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Lu R; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: lurenquan@126.com.

Biochem Biophys Res Commun ; 507(1-4): 74-82, 2018 12 09.

Article em En | MEDLINE | ID: mdl-30454896

Assuntos

Apoptose; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Proteínas de Ciclo Celular/metabolismo; Proteínas Associadas aos Microtúbulos/metabolismo; Proteínas Nucleares/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Proteína Supressora de Tumor p53/metabolismo; Apoptose/genética; Neoplasias da Mama/genética; Linhagem Celular Tumoral; Movimento Celular/genética; Proliferação de Células/genética; Inibidor de Quinase Dependente de Ciclina p21/metabolismo; Bases de Dados Genéticas; Regulação para Baixo/genética; Feminino; Regulação Neoplásica da Expressão Gênica; Inativação Gênica; Humanos; Pessoa de Meia-Idade; Ensaio Tumoral de Célula-Tronco

Palavras-chave

AKT signaling pathway; Breast cancer; Cell apoptosis; TPX2; p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Proteínas Nucleares / Transdução de Sinais / Proteína Supressora de Tumor p53 / Apoptose / Proteínas de Ciclo Celular / Fosfatidilinositol 3-Quinases / Proteínas Proto-Oncogênicas c-akt / Proteínas Associadas aos Microtúbulos Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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